The CO2-SMART Center aims to enable and accelerate safe, reliable, efficient, and cost-effective CO2 storage implementation through collaborative research and technology development. To accomplish its goals, the Center will focus on technological advances in the following six complementary research Thrust Areas: (1) site screening and characterization, including fluid, rock, and fracture properties; (2) multiscale and multi-physics modeling and simulation for prediction of CO2 displacement in storage aquifers; (3) cost-effective monitoring and characterization, including geophysical, geochemical, and geomechanical monitoring for high-resolution imaging; (4) machine learning and data analytics for flexible and efficient workflows, including multiphysics data processing, predictive modeling, and decision support tools; (5) risk assessment and uncertainty quantification for complex multi-physics subsurface storage systems, to inform risk mitigation strategies; (6) improving the economics of GCS through optimization and field development planning. Through cooperative research projects, the Center will focus on real issues and challenges that are identified and prioritized by its IAB members.